What is the main role of the buffering agent in local anaesthetic solutions?

The main role of the buffering agent in local anesthetic solutions is to neutralize pH and reduce discomfort. Local anesthetics can be acidic when formulated, and this acidity can lead to stinging or burning sensations upon injection, which can be uncomfortable for the patient. By incorporating a buffering agent, the pH of the solution is adjusted closer to that of the body’s tissues. This neutralization minimizes discomfort during the administration of the anesthetic by making the solution less irritating. Additionally, a more neutral pH can enhance the efficacy of the local anesthetic by improving its stability and absorption into the nerve tissues, allowing for faster onset and prolonged action while also contributing to patient comfort.